Director, CHA
University Cancer Prevention Research Center, 605 Yeoksam-dong,
Gangnam-gu, Seoul 135-081, Korea
Professor, Department of Gastroenterology, CHA University Medical Center Bundang
Hospital, 59 Yatap-ro, Bundang-gu,
Seongnam city 463-712, Korea
hahmkb@hotmail.com, hahmkb@cha.ac.kr
Topic: "FAT, fat, and remedy for GI diseases"
Education
1977-1983 Medical Degree (MD)
Yonsei
University College of Medicine, Seoul
1984-1986 Master of Medicine (Field of
Internal Medicine)
The
Graduate School, Yonsei University, Seoul
1986-1992 Doctor of Philosophy (Ph.D)
(Field of Gastroenterology)
The
Graduate School, Yonsei University, Seoul
1997-1999 Post-Doc and Research Associate
Lab
of Cell regulation and Carcinogenesis, NCI, NIH, Bethesda, USA
2006-present American
Gastroenterology Association Fellow (AGAF)
Medical
Certification
1983 Licensure in Medicine (License No. 25462)
1987 Diplomate, Korean Board of Internal
Medicine (License No. 2358)
1994 Subspecialty Board of Gastroenterology
(Certificate No 198) & Gastrointestinal
Endoscopy
(Certificate No. 94-197)
Appointments
1983-1984 Internship, Severance Hospital,
Yonsei University, Seoul
1984-1987 Resident in Internal Medicine
Severance
Hospital, Yonsei University, Seoul
1990-1992 Fellow in the field of Gastroenterology
Severance
Hospital, Department of Internal Medicine
1992-1994
Instructor of Medicine at Severance Hospital,
Department of Internal
Medicine, Yonsei University, College of
Medicine, Seoul
1994-1997 Assistant Professor of Medicine
Ajou
University School of Medicine, Suwon
1997-1999 Research Fellow & Associate
Laboratory
of Cell Regulation and Carcinogenesis,
National Cancer Institute, Bethesda, MD
1999-2003 Associate Professor of Medicine
Ajou University School of Medicine, Suwon
2003-2006 Professor
of Medicine at Ajou University School of Medicine
2001-2006 Director, Genomic Research Center for
Gastroenterology
1999-present Vice
President/ Director, Financial Committee
The Korean Society for Free Radical Research
2005-2006 Programe Manager (PM) in the field of Clinical
Medicine
The Korea Research
Foundation (KRF)
2004-2009 Vice President/Auditor, The Korean Society
of Cancer Prevention
2007-2008 Director, Digestive Disease Center, DMC
2007-2008 Director, DMC-Mecox Biomedicine Research Center,
DMC
2009 – 2012 Professor, Gachon Graduate
School of Medicine
Professor, Lee Gil
Ya Cancer and Diabetes Institute, Gachon University
Director, Regional
Cancer Center and Cancer Research Center
2012. 9 – present
Professor, CHA
University College of Medicine
Director, CHA Cancer
Prevention Research Center
Vice director, CHA
Medical Center Bundang Hospital
Research Field
Basic:
Mucosal damage and repair, Carcinogenesis, Chemoprevention
Clinic:
Gastroenterology and GI Endoscopy (diagnostic)
Publication
Lists, International peer review journal (SCI only)
2017
1) Lee HJ, Park JM, Hahm KB. Mitigated
NSAID-induced apoptotic and autophagic cell death with Smad7 overexpression. J
Clin Biochem Nutr 2017;60:55-62.
2) Bae JS, Park JM, Lee J, Oh BC, Jang SH, Lee YB, Han
YM, Ock CY, Cha JY, Hahm KB. Amelioration of non-alcoholic fatty liver
disease with NPC1L1-targetedted IgY or n-3 polyunsaturated fatty acids in mice.
Metabolism 2017;66:32-44
3) Ock CY, Park JM, Han YM, Jeong M, Kim MY, Lee HJ, Hahm
KB. Genetic ablation or pharmacologic inhibition of autophagy mitigated
NSAID-associated gastric damages. J Mol Med 2017;5:405-416.
2016
1)
Lee HJ, Park
JM, Han YM, Gil HK, Chang JY, Jeong M, Go EJ, Hahm KB. The role of chronic inflammation in the development of
gastrointestinal cancers; reviewing cancer prevention with natural
anti-inflammatory intervention. Expert Rev Gastroenterol Hepatol
2016;10:129-139.
2)
Han YM, Kim
KJ, Jeong M, Park JM, Go EJ, Kang JX, Hong SP, Hahm KB. Suppressed Helicobacter
pylori-associated gastric tumorigenesis in Fat-1 transgenic mice producing
endogenous ?-3 polyunsaturated fatty acids. Oncotarget 2016; Aug 12 Epub ahead
of print
3)
Han YM,
Jeong M, Park JM, Kim MY, Go EJ, Cha JY, Kim KJ, Hahm KB. The w-3 polyunsaturated fatty acids prevented
colitis-associated carcinogenesis through blocking dissociation of b-catenin
complex, inhibiting COX-2 through repressing NF-kB, and inducing
15-prostaglandin dehydrogenase. Oncotarget 2016; August 15 Epub ahead of print.
4)
Kim MY, Han
YM, Park JM, Hahm KB. GI-safer
aspirin: sometimes sugar coating helps. Dig Dis Sci 2016;61:2151-3.
5)
Ko WJ, Song
GW, Hahm KB, Hong SP, Cho JY, Cho
JH, Jin SY. Tissue diagnosis
of GI subepithelial tumor only through Trucut biopsy under a forward-viewing
endoscope: applicability as newer diagnostic modality. Surg Endosc 2016, May
18, Epub ahead of print.
6)
Song JH, Han
YM, Kim WH, Park JM, Jeong M, Go EJ, Hong SP, Hahm KB. Oxidative stress from reflux esophagitis to esophageal
cancer: the alleviation with antioxidants. Free Rad Res 2016;19:1-12.
7)
Song JH, Ko
WJ, Song GW, Hahm KB, Cho JY. Urgent hemostasis of active appendiceal bleeding
by intra-appendiceal stent insertion and detachable snare wrapping.
Gastrointest Endosc 2016, Apr 19 Epub ahead of print.
8)
Lee S, Park
JM, Jeong M, Han YM, Go EJ, Ko WJ, Cho JY, Kwon CI, Hahm KB. Korean red ginseng ameliorated experimental
pancreatitis through the inhibition of hydrogen sulfide in mice. Pancreatology
2016;16:326-336.
9)
Lee
EH, Kwon O, Hahm KB, Kim W, Kim JI,
Cheong DY, Kim YJ, Kim JH, park JJ, Joo MK. Irritable bowel syndrome-specific
health-related quality of life instrument: development and psychometric
evaluation. Health Qual Life Outcomes 2016;14:22.
10) Kim HY, Kwon HY, Ha Thi HT, Lee HJ, Kim GI, Hahm KB, Gong S. MicroRNA-132 and microRNA-223 control positive
feedback circuit by regulating FOXO3a in inflammatory bowel disease. J
Gastroenterol Hepatol 2016; Feb 15, Epub ahead of print.
11) Kangwan N, Kim YJ, Han YM, Jeong M, Park JM, Go EJ, Hahm KB. Sonic hedgehog inhibitors prevent colitis-associated cancer via
orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2
abrogation, and tumorsphere inhibition. Oncotarget 2016;7:7667-82.
2015
1) Ryu EK, Kim TH, Jang EJ, Choi YS, Kim ST, Hahm KB, Lee HJ. Wogonin, a plant
flavone from Scutellariae radix, attenuated ovalbumin-induced airway
inflammation in mouse model of asthma via the suppression of IL-4/STAT6
signaling. J Clin Biochem Nutr. 2015
Sep;57(2):105-12. Epub 2015 Jul
2) Kangwan N, Kim YJ, Han YM, Jeong M, Park JM, Hahm KB. Concerted actions of
ameliorated colitis, aberrant crypt foci inhibition, and
15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led
to prevention of colitis-associated cancer. Int J Cancer. 2015 Oct 17.
3) Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho
JY, Hahm KB. Dietary prevention of
Helicobacter pylori-associated gastric cancer with kimchi. Oncotarget. 2015 Oct 6;6(30):29513-26. doi:
10.18632/oncotarget.4897.
4) Nguyen TT, Kim SJ, Park JM, Hahm KB, Lee HJ.Repressed TGF-? signaling through CagA-Smad3 interaction as pathogenic
mechanisms of Helicobacter pylori-associated gastritis. J Clin Biochem Nutr.
2015 Sep;57(2):113-20. Epub 2015 Jul 30.
5) Han YM, Park JM, Jeong M, Yoo JH, Kim WH, Shin SP, Ko WJ,
Hahm KB. Dietary, non-microbial intervention to prevent
Helicobacter pylori-associated gastric diseases. Ann Transl Med. 2015
Jun;3(9):122.
6)
Park JM, Han
YM, Jeong M, Kim EH, Ko WJ, Cho JY, Hahm
KB. Omega-3 polyunsaturated fatty acids as an angelus custos to rescue
patients from NSAID-induced gastroduodenal damage. J Gastroenterol. 2015 Jun;50(6):614-25. Epub
2015 Jan 13.
7) Han YM, Park JM, Kangwan N, Jeong M, Lee S, Cho JY, Ko
WJ, Hahm KB. Role of proton pump inhibitors in preventing
hypergastrinemia-associated carcinogenesis and in antagonizing the trophic
effect of gastrin. J Physiol Pharmacol.
2015 Apr;66(2):159-67.
8) Jeong M, Park JM, Han YM, Kangwan N, Kwon SO, Kim BN, Kim
WH, Hahm KB.Dietary Intervention of
Artemisia and Green Tea Extracts to Rejuvenate Helicobacter pylori-Associated
Chronic Atrophic Gastritis and to Prevent Tumorigenesis. Helicobacter. 2015 Apr 10.
9) Park JM, Kim JW, Hahm
KB. HSPA4, the "Evil
Chaperone" of the HSP Family, Delays Gastric Ulcer Healing. Dig Dis Sci.
2015 Apr;60(4):824-6. Epub 2015 Mar 3.
10) Kwon CI, Kim G, Ko KH, Jung Y, Chung IK, Jeong S, Lee DH,
Hong SP, Hahm KB. Bio-sheet graft
therapy for artificial gastric ulcer after endoscopic submucosal dissection: an
animal feasibility study. Gastrointest
Endosc. 2015 Apr;81(4):989-96.. Epub 2014 Dec 5.
11) Park JM, Han YM, Lee JS, Ko KH, Hong SP, Kim EH, Hahm KB. Nrf2-mediated mucoprotective
and anti-inflammatory actions of Artemisia extracts led to attenuate stress
related mucosal damages. J Clin Biochem Nutr. 2015 Mar;56(2):132-42. Epub 2014
Nov 28.
12) Song GW, Ko WJ, Kim WH, Hahm KB, Hong SP, Cho JY. Peroral endoscopic myotomy for esophageal
muscular ring. Endoscopy. 2015;47 Suppl 1 UCTN:E387-8. Epub 2015 Aug 14.
13) Fukudo S, Hahm KB,
Zhu Q, Sollano JD, Rani AA, Syam AF, Kachintorn U, Suzuki H, Kamiya T, Joh T,
Uchiyama K, Naito Y, Takahashi S, Kinoshita Y, Ueno F, Yamagami H, Chan FK,
Fock KM, Arakawa T; International Gastrointestinal Consensus Symposium Study
Group. Survey of clinical practice for irritable bowel syndrome in East asian
countries. Digestion. 2015;91(1):99-109 Epub 2015 Jan 20.
14) Park JM, Jeong M, Kim EH, Han YM, Kwon SH, Hahm KB. Omega-3 Polyunsaturated Fatty
Acids Intake to Regulate Helicobacter pylori-Associated Gastric Diseases as
Nonantimicrobial Dietary Approach. Biomed Res Int. 2015;2015:712363. Epub 2015
Aug 3
15) Kangwan N, Kim YJ, Han YM, Jeong M, Park JM, Go EJ, Hahm
KB. Sonic gedgehog inhibitors prevent colitis-associated cancer via
orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, and Bcl-2
abrogation, and tumorsphere inhibition. Oncotarget 2015; Dec 26, 2015
16) Park JM, Lee HJ, Yoo JH, Ko WJ, Cho JY, Hahm KB. Overview
of gastrointestinal cancer prevention in Asia. Best Pract Res Clin
Gastroenterol 2015;29:855-867.
17) Han YM, Park JM, Cha JY, Jeong M, Go EJ, Hahm KB.
Endogenous conversion of w-6 to w-3 polyunsaturated fatty acids in fat-1
transgenic mice attenuated intestinal polyposis by either inhibiting
COX-2/b-carotein signaling or activating 15-PGDH.IL-18. Int J Cancer 2015; Dec
9.
18) Kangwan N, Kim YJ, Han YM, Jeong M, Park JM, Hahm KB.
Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and
15-PGDH induction by sonic hedgehog inhibitor led to prevention of
colitis-associated cancer. Int J Cancer 2015;Oct 17.
19) Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho
JY, Hahm KB. Dietary prevention of Helicoabcter pylori-associated gastric
cancer with Kimchi. Oncotarget 2015; 6:29513-26.
20) Ko WJ, Song GW, Hong SP, Kwon CI, Hahm KB, Cho CY. Novel
3-D printing technique for caps to enable tailored therapeutic endoscopy. Dig
Endosc 2015:Sep 7.
21) Ryu EK, Kim TH, Jang EJ, Choi YS, Kim ST, Hahm KB, Lee
HJ. Wogonin, a plant flavones from S. radix, attenuated ovalbimun-induced
airway inflammation in mouse model of asthma via the suppression of IL-4/STAT6
signaling. J Clin Biochem Nutr 2015; 57:105-12.
22) Nguyen TT, Kim SJ, Park JM, Hahm KB, Lee HJ. Repressed
TGF-b signaling through Cag-A-smad3 interaction as pathogenic mechanisms of
Helicoabcter pylori-associated gastritis. J Clin Biochem Nutr 2015;57:113-20.
23) Park JS, Yi TG, Park JM, Han YM, Shin DH, Tak SJ, Lee K,
Jeon MS, Hahm KB, Song SU, Park SH. Therapeutic effects of mouse bone
marrow-derived clonal mesenchymal stem cells in a mouse model of inflammatory
bowel disease. J Clin Biochem Nutr 2015;57:192-203.
2014
1)
Park JM, Han
YM, Kangwan N, Lee SY, Jung MK, Kim EH, Hahm
KB. S-allyl cysteine alleviates
nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by
increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone
deacetylation inhibition. J
Gastroenterol Hepatol. 2014 Dec;29 Suppl 4:80-92.
2)
Kangwan N, Park JM, Hahm KB.
Development of GI-safe NSAID; progression from the bark of willow tree to
modern pharmacology. Curr Opin Pharmacol. 2014 Dec;19:17-23.
3)
Park JM, Han NY, Han YM, Chung MK, Lee HK, Ko KH, Kim EH, Hahm KB. Predictive proteomic
biomarkers for inflammatory bowel disease-associated cancer: where are we now
in the era of the next generation proteomics? World J Gastroenterol. 2014 Oct
7;20(37):13466-2476.
4)
Park JM, Lee
S, Chung MK, Kwon SH, Kim EH, Ko KH, Kwon CI, Hahm KB.
Antioxidative phytoceuticals to ameliorate
pancreatitis in animal models: an answer from nature. World J Gastroenterol.
2014 Nov 28;20(44):16570-81.
5)
Park JM,
Park SH, Hong KS, Han YM, Jang SH, Kim EH, Hahm
KB. Special licorice extracts
containing lowered glycyrrhizin and enhanced licochalcone A prevented
Helicobacter pylori-initiated, salt diet-promoted gastric tumorigenesis.
Helicobacter. 2014 Jun;19(3):221-36. Epub 2014 Mar 20.
6)
Kim YH, Kim
G, Kwon CI, Kim JW, Park PW, Hahm KB TWIST1 and SNAI1 as markers of poor prognosis
in human colorectal cancer are associated with the expression of ALDH1 and TGF-?1. Oncol
Rep. 2014 Mar;31(3):1380-8. Epub 2014 Jan 8.
7)
Han YM, Hahm KB, Park JM, Hong SP, Kim EH.
Paradoxically augmented anti-tumorigenic action of proton pump inhibitor and
GastrininAPCMin/+ intestinal polyposis model. Neoplasia. 2014 Jan;16(1):73-83.
2013
1)
Hong H, Kim
EH, Lee HJ, Kim YJ, Lee JJ, Hahm KB.
Molecular mechanisms elucidating why old stomach is more vulnerable to
indomethacin-induced damage than young stomach. Dig Dis Sci. 2013
Jan;58(1):61-71. Epub 2012 Jul 29.
2)
Han NY, Choi W,
Park JM, Kim EH, Lee H, Hahm KB. Label-free quantification for discovering
novel biomarkers in the diagnosis and assessment of disease activity in
inflammatory bowel disease. J Dig Dis. 2013 Apr;14(4):166-74.
3)
Chun KS, Kim EH,
Lee S, Hahm KB. Chemoprevention of gastrointestinal cancer: the reality
and the dream. Gut Liver. 2013 Mar;7(2):137-49.
4)
Kim WH, Hahm
KB. Endoscopically
diagnosed gastric cancers: looking alike, but behave differently. Clin Endosc. 2013 Mar;46(2):111-2. Epub 2013 Mar 31.
5)
Choi KS, Song H, Kim EH, Choi JH, Hong H, Han
YM, Hahm KB. Inhibition of
Hydrogen Sulfide-induced Angiogenesis and Inflammation in Vascular Endothelial
Cells: Potential Mechanisms of Gastric Cancer Prevention by Korean Red Ginseng.
J Ginseng Res. 2012 Apr;36(2):135-45.
6)
Park SH, Hong H,
Han YM, Kangwan N, Kim SJ, Kim EH, Hahm
KB. Nonsteroidal anti-inflammatory drugs (NSAID) sparing effects of
glucosamine hydrochloride through N-glycosylation inhibition; strategy to rescue
stomach from NSAID damage. J Physiol Pharmacol. 2013 Apr;64(2):157-65.
7)
Kwon KA, Choi
IJ, Kim EY, Dong SH, Hahm KB. Highlights
of the 48th seminar of korean society of gastrointestinal endoscopy. Clin
Endosc. 2013 May;46(3):203-11Epub 2013 May 31.
8)
Kim WH, Park PW,
Hahm KB, Hong SP. Endoscopic
treatment of refractory gastroesohageal reflux disease. Clin Endosc. 2013
May;46(3):230-4. Epub 2013 May 31.
9)
Kwon CI, Song
SH, Hahm KB, Ko KH. Unusual
complications related to endoscopic retrograde cholangiopancreatography and its
endoscopic treatment. Clin Endosc. 2013 May;46(3):251-9. Epub 2013 May 31.
10)
Yo I, Chung JW,
Jeong MH, Lee JJ, An J, Kwon KA, Rim MY, Hahm
KB. .Huge liposarcoma of esophagus resected by endoscopic submucosal
dissection: case report with video. Clin Endosc. 2013 May;46(3):297-300. Epub
2013 May 31.
11)
Park JM, Kim YJ,
Kim JS, Han YM, Kangwan N, Hahm KB,
Kim TS, Kwon O, Kim EH. Anti-inflammatory and carbonic anhydrase restoring
actions of yam powder (Dioscorea spp) contribute to the prevention of cysteamine-induced
duodenal ulcer in a rat model. Nutr Res. 2013 Aug;33(8):677-85. Epub 2013 Jul
8.
12)
Ko KH, Hahm KB. Harmony of Duet over Solo: Use
of Midazolam or Propofol for Sedative Endoscopy in Pediatric Patients. Clin
Endosc. 2013 Jul;46(4):311-2. Epub 2013 Jul 31.
13)
Han YM, Park JM,
Park SH, Hahm KB, Hong SP, Kim EH. Gastrin
promotes intestinal polyposis through cholecystokinin-B receptor-mediated
proliferative signaling and fostering tumor microenvironment. J Physiol
Pharmacol. 2013 Aug;64(4):429-37.
14)
Kwon KA, Choi
IJ, Kim EY, Dong SH, Hahm KB. Highlights
of international digestive endoscopy network 2013. Clin Endosc. 2013
Sep;46(5):425-35. Epub 2013 Sep 30.
15)
Kwon CI, Ko KH, Hahm KB, Kang DH. Functional
Self-Expandable Metal Stents in Biliary Obstruction. Clin Endosc. 2013
Sep;46(5):515-521. Epub 2013 Sep 30. Review.
16)
Song SH, Kim KW,
Kim WH, Kwon CI, Ko KH, Hahm KB,
Park PW, Hong SP. Gastrointestinal cancers in a peutz-jeghers syndrome family:
a case report.. Clin Endosc. 2013 Sep;46(5):572-5. Epub 2013 Sep 30.
17)
Cheon JH, Hahm KB. Perfecting video capsule
endoscopy: is there need for training? Clin Endosc. 2013 Nov;46(6):599-600.
Epub 2013 Nov 19.
18)
Ko KH, Kwon CI,
Park SH, Han NY, Lee HK, Kim EH, Hahm KB.
Application of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight
Imaging Mass Spectrometry (MALDI-TOF IMS) for Premalignant Gastrointestinal
Lesions. Clin Endosc. 2013 Nov;46(6):611-619. Epub 2013 Nov 19. Review.
2012
1) Kim JH, Kim EH, Ock C, Hong H, Kim YJ,
Kwon KA, Park DK, Hahm KB.
Mitigating endoplasmic reticulum stress with revaprazan ameliorates
stress-related mucosal disease. J Gastroenterol Hepatol 27:120-129, 2012
2) Ock C, Kim EH, Choi DJ, Lee HJ, Hahm
KB, Chung MH. 8-hydroxydeoxyguanosine; not biomarker for oxidative stress, but
remedy for oxidative stress-implicated GI duseases. World J Gastroenterol 18:302-308,
2012
3) Ha M, Chung JW, Hahm KB, Kim YJ, Lee W, An J, Kim DK, Kim MG. A case of Cowden
syndrome diagnosed from multiple gastric polyposis. World J Gastroenterol
18:861-864, 2012
4) Choi KS, Kim EH, Hong H, Ock C, Lee JS, Kim JH, Hahm KB. Attenuation of
cysteamine-induced duodenal ulcer with Cochinchina
mormordia seed extract through inhibiting cPLA2/5-LOX and
activating g-GCS. J Gastroenterol Hepatol (in press, 2012).
5) Kim YJ, Kim EH, Hahm KB. Oxidative stress in inflammation-based gastrointestinal
tract diseases; challenge and opportunities. J Gastroenterol Hepatol (in press,
2012)
6) Kim EH, Hong H, Hong KS, Choi KS, Han
YM, Kangwan N, Cho YJ, Hahm KB. High
concentrated probiotics improve inflammatory bowel diseases better than
commercial concentration of probiotics. JFDA (in press, 2012).
7) Kim JH, Kim YJ, Lee JJ, Chung JW, Kwon KA, Kim JH,
Hahm KB. The efficacy of self-expanding metal stents for colorectal obstruction
with unresectable stage IVB colorectal cancer. Hepatogastroenterology. 2012 Nov-Dec;59(120):2472-6.
8)
Kim
JH, Jung ES, Jeong SH, Kim JS, Ku YS, Hahm KB, Kim JH, Kim YS. A case of emphysematous hepatitis
with spontaneous pneumoperitoneum in a patient with hilar cholangiocarcinoma.
Korean J Hepatol. 2012 Mar;18(1):94-7. Epub 2012 Mar 22
9)
Ha M, Kim YJ,
Kwon KA, Hahm KB, Kim MJ, Kim DK, Lee YJ, Oh SP. Gastric angiodysplasia
in a hereditary hemorrhagic telangiectasia type 2 patient. World J
Gastroenterol. 2012 Apr 21;18(15):1840-4.
10)
Lee JH, An CS,
Yun BS, Kang KS, Lee YA, Won SM, Gwag BJ, Cho SI, Hahm KB. Prevention
effects of ND-07, a novel drug candidate with a potent antioxidative action and
anti-inflammatory action, in animal models of severe acute pancreatitis. Eur J
Pharmacol. 2012 Jul 15;687(1-3):28-38. Epub 2012 May 3.
11)
Jeong MH, Chung JW, Lee SJ, Ha M, Jeong SH, Na
S, Na BS, Park SK, Kim YJ, Kwon KA, Ko KI, Jo Y, Hahm KB, Jung HY Comparison
of rifabutin- and levofloxacin-based third-line rescue therapies for
Helicobacter pylori. Korean J Gastroenterol. 2012 Jun 25;59(6):401-6. Korean.
12)
Chung JS, Park S,
Park SH, Park ER, Cha PH, Kim BY, Chung YM, Woo SR, Han CJ, Kim SB, Suh KS,
Jang JJ, Lee K, Choi DW, Lee S, Lee GY, Hahm KB, Shin JA, Kim BS, Noh
KH, Kim TW, Lee KH, Yoo YD. Overexpression of Romo1 promotes production of
reactive oxygen species and invasiveness of hepatic tumor cells. Gastroenterology.
2012 Oct;143(4):1084-94.e7.
13)
Hong H, Kim EH,
Lee HJ, Kim YJ, Lee JJ, Hahm KB. Molecular
mechanisms elucidating why old stomach is more vulnerable to
indomethacin-induced damage than young stomach. Dig Dis Sci. 2013
Jan;58(1):61-71.
14)
Naito Y, Uchiyama
K, Kinoshita Y, Fukudo S, Joh T, Suzuki H, Takahashi S, Ueno F, Fujiwara Y,
Arakawa T, Matsumoto T, Hahm KB, Kachintorn U, Syam AF, Rani AA, Sollano
JD, Zhu Q. A questionnaire-based survey on screening for gastric and colorectal
cancer by physicians in East Asian countries in 2010. Digestion.
2012;86(2):94-106
15)
Chung JW, Jung
YK, Kim YJ, Kwon KA, Kim JH, Lee JJ, Lee SM, Hahm KB, Lee SM, Jeong JY,
Yun SC. Ten-day sequential versus triple therapy for Helicobacter?pylori eradication: a prospective, open-label,
randomized trial. J Gastroenterol Hepatol. 2012 Nov;27(11):1675-80.
16)
Lee JS, Cho JY,
Song H, Kim EH, Hahm KB. Revaprazan, a novel acid pump antagonist,
exerts anti-inflammatory action against Helicobacter pylori-induced COX-2
expression by inactivating Akt signaling. J Clin Biochem Nutr. 2012
Sep;51(2):77-83.
17)
Kwon KA, Choi IJ,
Bak YT, Dong SH, Hahm KB. International digestive endoscopy network
2012: a patchwork of networks for the future. Clin Endosc. 2012
Sep;45(3):209-10. Epub 2012 Aug 22.
18)
Kim EH, Bae JS, Hahm
KB, Cha JY. Endogenously synthesized n-3 polyunsaturated fatty acids in
fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. Biochem
Pharmacol. 2012 Nov 15;84(10):1359-6. Epub 2012 Sep 6.
19)
Han NY, Kim EH,
Choi J, Lee H, Hahm KB. Quantitative proteomic approaches in biomarker
discovery of inflammatory bowel disease. J Dig Dis. 2012 Oct;13(10):497-503.
20)
Lee HJ, Han YM,
Kim EH, Kim YJ, Hahm KB. A possible involvement of Nrf2-mediated heme
oxygenase-1 up-regulation in protective effect of the proton pump inhibitor
pantoprazole against indomethacin-induced gastric damage in rats. BMC
Gastroenterol. 2012 Oct 16;12:143.
21)
Kamiya T, Joh T,
Sollano JD, Zhu Q, Kachintorn U, Aziz Rani A, Hahm KB, Takahashi S,
Kinoshita Y, Matsumoto T, Naito Y, Takeuchi K, Arakawa T, Terano A. Consensus
of the present and prospects on endoscopic diagnosis and treatment in East
asian countries. Diagn Ther Endosc. 2012;2012:808365.
2011
1)
Ock CY, Hong
KS, Choi KS, Chung MH, Kim Y, Kim JH, Hahm
KB. A novel approach for stress-induced gastritis based on paradoxical
anti-oxidative and anti-inflammatory action of 8-hydroxydeoxyguanosine. Biochem
Pharmacol 81:111-122, 2011
2)
Chan Young Ock
1, Yun Jung Lim 2, Yoon Jae Kim 3, Jeong Sang Lee
1, Jun Weon Chung 3, Dong Kyun Park 3, Ju Hyun Kim 3
and Ki Baik Hahm 1,3, * The Novel Acid Pump Antagonist, Revaprazan, Protects
NSAIDs-Induced Gastropathy through the Preservation of Heat Shock Protein 27,
J Dig Dis (in press, 2011).
3)
Ock CY, Kim
EH, Hong H, Hong KS, Han YM, Choi KS, Hahm
KB, Chung MH. Prevention of colitis-associated colorectal cancer with
8-hydroxydeoxyguanosine. Cancer Prev Res 4:1507-1521, 2011
4)
Won I, Kim YJ,
Kim SJ, Kim EH, Hahm KB.
Nutrigenomic approach to tackle the unpleasant journey to Helicobacter pylori-associated gastric carcinogenesis. J Dig Dis
12:157-164, 2011
5)
Ock CY, Lim
YJ, Kim YJ, Chung JW, Kwon KA, Kim JH, Hahm
KB. Acid pump antagonist-provoked HSP27 dephosphorylation and accentuation
rescues stomach from indomethacin-induced damages. J Dig Dis 12:71-81, 2011.
2010
1)
Jun Won Chung, Ki Baik Hahm Rejuvenation of atrophic gastritis in
the elderly. J Gastroenterolo Hepatol 25:434-435, 2010.
2)
Yeon Suk Kim, Ki Baik Hahm Endotherapy of pancreaticobiliart
fistula; second to none strategy for cure. J Gastroenterol Hepatol 25:, 2010
3) Lee KM, Lee JS, Jung HS, Park DK, Park HS, Hahm KB Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: Implication for gastric carcinogenesis. Cancer Lett. 287:44-53, 2010.
4)
Kim YJ, Chung JW, Lee SJ, Choi KS, Kim JH, Hahm KB. Progression from chronic atrophic gastritis to gastric
cancer; tangle, toggle, tackle with Korea red ginseng. J Clin Biochem Nutr. 2010 May;46(3):195-204. Epub 2010 Apr 10.
5) Ho Jae Lee1,
Chan Young Ock2, Seong-Jin Kim3, Ki-Baik Hahm2,4
Heat shock protein; hard worker or bad offender for gastric diseases.
Int J Proteomics 2010:259163 Epub,
2010
6) Jo Y, Han SU, Kim YJ, Kim JH, Kim ST, Kim SJ, Hahm KB. Suppressed Gastric
Mucosal TGF-beta1 Increases Susceptibility to H. pylori-Induced Gastric
Inflammation and Ulceration: A Stupid Host Defense Response. Gut
Liver.
2010 Mar;4(1):43-53. Epub 2010 Mar 25.
7) Hong S, Lee HJ, Kim SJ, Hahm KB. Connection between
inflammation and carcinogenesis in gastrointestinal tract: focus on TGF-beta
signaling. World J Gastroenterol. 2010 May 7;16(17):2080-93.
8) Yoon Jae Kima,
Kyung Sook Hongb, Jun Won Chunga, Ju Hyun Kima,
Ki Baik Hahma, b, * Prevention of colitis-associated carcinogenesis
with infliximab; top-down strategy for colitic cancer prevention, Cancer Prevention
Research 3:1314-1333, 2010.
9) Yoon Jae Kim1,
Jeong Sang Lee2, Kyung Sook Hong2, Jun Weon Chung1,
Ju Hyun Kim1, Ki Baik Hahm1,2 Novel
application of proton pump inhibitor for the prevention of colitic cancer
beyond acid suppression.
Cancer Prevention Research 3:963-974, 2010
10) Jung Gon Kim, Yoon Jae Kim,
*Seung Hee Yoo, Jeong Sang Lee, Joon Won Chung, **Min Ho Kim, Ki-Baik Hahm. Halimeter ppb levels as the predictor of erosive
gastroesophageal reflux disease. Gut and Liver 4:320-325, 2010.
11) Chan Young Ock and Ki-Baik Hahm. Oxygen free radicals in
gastric mucosal damages. Monograph on “Free Radical in
Digestive Disease” Karger Press (2010, December)
12) So Jung Lee1, Ji Young Park1,
Ki Seok Choi2, Chan Young Ock2, Kyung Sook Hong2,
Yoon Jae Kim1, Jun Weon Chung1, and Ki-Baik Hahm1,2* Efficacy of
Korean Red Ginseng Supplementation on Eradication Rate and Gastric Volatile
Sulfur Compound Levels after Helicobacter pylori Eradication Therapy. J
Ginseng Res (2010, June)
13) Jun Weon Chung, Yoon Jae Kim, So Jung Lee, and Ki Baik Hahm*Korean Red
Ginseng: Qualitative and Quantitative Benefits on Helicobacter pylori
Infection. J Ginseng Res (2010, June)
14) Yun Jeong Lim1, Won Gun Kwack1, Jin Ho Lee1,
Youg-Sup Lee2, Ki Baik Hahm3,
and Young-Kwon Kim1, *Increased pulse wave velocity reflecting arterial
stiffness in patients with colorectal adenomas. J Clin Biochem Nutr 47:261-265,
2010
2009
1) Lim YJ, Lee JS, Ku YS, Hahm KB Rescue strategies against NSAID-induced gastroduodenal damage. J Gastroenterol Hepatol 2009, 24:1169-1178, 2009.
2)
Lee HW; Hahm
KB; Lee JS, Ju YS; Lee KM, Lee KW.Association of the HLA class II Alleles
with Chronic Atrophic Gastritis and Gastric Carcinoma in Koreans. J Dig Dis 10:265-267, 2009.
3)
Lee JS, Kwon KA, Jung HS, Kim JH, Hahm KB. Korea red ginseng on Helicobacter pylori-induced halitosis;
newer therapeutic strategy and plausible mechanism. Digestion 80:192-199, 2009.
4)
Li CS, Zhang Q, Lee KJ, Cho SW, Lee KM, Hahm KB, Choi SC, Yun KJ, Chung HT,
Chae SC. Interleukin 27 polymorphisms are associated with inflammatory bowel
disease in a Korean population. J Gastroenterol Hepatol 24:1692-1696, 2009.
5)
Fujiwara Y, Takahashi SI, Arakawa T,
Sollano JD, Zhu Q, Kachintorn U, Rani A, Hahm
KB, Joh T, Kinoshita Y, Matsumoto T, Naito Y, Takeuchi K, Furuta K, Terano
A. 2008 Questionnaire-Based Survey of Gastroesophageal Reflux Disease and
Related Diseases by Physicians in East Asian Countries. Digestion. 2009 Jul
27;80(2):119-128.
6)
Choi SR, Lee SA, Kim YJ, Ok CY, Lee HJ, Hahm KB. Role of heat shock proteins in gastric inflammation and ulcer healing.
J Physiol Pharmacol. 2009 Dec;60 Suppl 7:5-17.
7)
Arakawa T, Fujiwara Y, Sollano JD, Zhu Q, Kachintorn U, Rani AA, Hahm KB, Takahashi S, Joh T, Kinoshita Y, Matsumoto T, Naito Y, Takeuchi K, Yamagami H, Agustanti N, Xiong H, Chen X, Jang EJ, Furuta K, Terano A; IGICS study group. A questionnaire-based survey on the prescription of non-steroidal
anti-inflammatory drugs by physicians in East Asian countries in 2007. Digestion. 2009;79(3):177-85. Epub 2009 Apr 3.
8) Lee JS, Paek NS, Kwon OS, Hahm KB. Anti-inflammatory
actions of probiotics through activating suppressor of cytokine signaling
(SOCS) expression and signaling in Helicobacter pylori infection: a novel
mechanism. J Gastroenterol Hepatol. 2010 Jan;25(1):194-202.
2008
1) Park SW, Oh TY, Kim YS, Sim H, Park SJ, Jang EJ, Park JS, Baik HW, Hahm KB Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats. J Gastroenterol Hepatol. 23(6):976-84; 2008.
2) Young Oh T, Ok Ahn B, Jung Jang E, Sang Park J, Jong Park S, Wook Baik H, Hahm KB. Accelerated Ulcer Healing and Resistance to Ulcer Recurrence with
Gastroprotectants in Rat Model of Acetic Acid-induced Gastric Ulcer. J Clin Biochem
Nutr. 42(3):204-14; 2008.
3)
Lee EH, Cheong JY, Cho SW, Hahm KB, Kim HY, Park JJ, Lee DH, Kim
SK, Choi SR, Lee ST, Moon SM. Development and psychometric evaluation of a
chronic liver disease-specific quality of life questionnaire. J Gastroenterol
Hepatol. 23(2):231-8; 2008
4)
Yoo SH, HS Jung, WS Sohn, BH Kim, BH Ku, YS
Kim, SW Park, KB Hahm Volatile Sulfur Compounds
as a Predictor for Esophagogastroduodenal Mucosal Injury Gut and
Liver 2:113~118, 2008
5)
Lim YJ, Kim
BH, Jung HS, Hahm KB. Strategy to
rescue from NSAID-induced GI damages. J Gastroenterol Hepatol (invited review,
in press).
6)
Chun SC, Kim
J, Hahm KB, Park YJ, Chun SH. Data
mining technique for medical informatics: detecting gastric cancer using
case-based reasoning and single nucleotide polymorphisms. Expert Systems.
25:163-172, 2008.
7)
Kim YS, Park
SW, Kim MH, Jang EJ, Park JS, Park SJ, Baik HW, Chung G, Hahm KB. Novel single nucleotide polymorphisms of the VEGF gene as
a risk factor for gastroduodenal ulcers. J Gastroenterol Hepatol (in press,
2008).
8)
Jang EJ, Park
SW, Park JS, Park SJ, Hahm KB, Naik
HW, Paik SY, Sin MK, Lee ES, Oh SW, Park CY. The influence of the eradication
of H. pylori on gastric ghrelin,
appetite, and body mass index in patients with peptic ulcer disease. J
Gastroenterol Hepatol (in press, 2008).
9)
Lee SY, Shin
YW, Hahm KB. Phytoceuticals; ignored
but mighty weapons against H. pylori
infection. J Dig Dis 9:129-139, 2008.
2007
1) Park S, Yeo M, Jin JH, Lee KM, Kim SS, Choi SY, Hahm KB. Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells. Dig Dis Sci. 2007 Apr;52(4):973-82. Epub 2007 Feb 27.
2) Lee JS, Kim HS, Hahm KB, Sohn MW, Yoo M, Johnson JA, Surh YJ. Inhibitory effects of 7-carboxymethyloxy-3',4',5-trimethoxyflavone (DA-6034) on Helicobacter pylori-induced NF-kappa B activation and iNOS expression in AGS cells. Ann N Y Acad Sci. 2007 Jan;1095:527-35.
3) Park S, Han SU, Lee KM, Park KH, Cho SW, Hahm KB. 5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection Helicobacter. 2007 Feb;12(1):49-58.
4) Kim BG, Lee DH, Ye BD, Lee KH, Kim BW, Kim SG, Kim SW, Kim SK, Kim JJ, Kim HY, Park JJ, Park CY, Baik GH, Lee YC, Lee JH, Lee JH, Chun HJ, Hahm KB, Hong SJ, Lee SW, Jung HC. Comparison of 7-day and 14-day proton pump inhibitor-containing triple therapy for Helicobacter pylori eradication: neither treatment duration provides acceptable eradication rate in Korea. Helicobacter. 2007 Feb;12(1):31-5.
2006
1)
Cheong JY, Cho SW, Hwang IL, Yoon SK, Lee JH, Park CS, Lee JE, Hahm KB, Kim JH. Association between chronic hepatitis B virus
infection and interleukin-10, tumor necrosis factor-alpha gene promoter
polymorphisms. J Gastroenterol Hepatol.
2006 Jul;21(7):1163-9
2) Lee JH, Kim JJ, Hahm KB, Lee DH, Kim N, Kim SK, Park JJ, Choi SR, Lee JH, Lee ST, Lee EH, Rhee JC. Efficacy and
safety of ecabet sodium on functional dyspepsia: a prospective, double-blinded,
randomized, multi-center controlled trial. World J Gastroenterol.
2006 May 7;12(17):2756-61
3) Lee EH, Hahm KB, Lee JH, Park JJ, Lee DH, Kim SK, Choi SR, Lee ST. Development
and validation of a functional dyspepsia-related quality of life (FD-QOL) scale
in South Korea. J Gastroenterol Hepatol.
2006 Jan;21(1 Pt 2):268-74.
4) Yeo M, Kim DK, Park HJ, Oh TY, Kim JH, Cho SW, Paik YK, Hahm KB. Loss of
transgelin in repeated bouts of ulcerative colitis-induced colon
carcinogenesis. Proteomics. 2006
Feb;6(4):1158-65.
5) Yeo M, Kim DK, Han SU, Lee JE, Kim YB, Cho YK, Kim JH, Cho SW, Hahm KB. Novel
action of gastric proton pump inhibitor on suppression of Helicobacter pylori
induced angiogenesis. Gut. 2006 Jan;55(1):26-33.
6) Cheong JY, Cho SW, Chung SG, Lee JA, Yeo M, Wang HJ, Lee JE, Hahm KB, Kim JH Genetic polymorphism of interferon-gamma, interferon-gamma receptor, and interferon regulatory factor-1 genes in patients with hepatitis B virus infection. Biochem Genet. 2006 Jun;44(5-6):246-55. Epub 2006 Aug 30.
2005
1)
Park S, Yeo M, Jin JH, Lee KM, Jung JY,
Choue R, Cho SW, Hahm KB. Rescue of Helicobacter pylori-induced cytotoxicity
by red ginseng. Dig Dis Sci. 2005 Jul;50(7):1218-27.
2)
2, Lee JS, Oh TY, Kim YK, Baik JH, So S, Hahm
KB, Surh YJ. Protective effects of green tea polyphenol extracts against
ethanol-induced gastric mucosal damages in rats: Stress-responsive
transcription factors and MAP kinases as potential targets. Mutat Res. 2005 Aug
8; [Epub ahead of print]
3)
Young Oh T, Yeo M, Uk Han S, Kwan Cho Y,
Bae Kim Y, Hee Chung M, Seok Kim Y, Won Cho S, Hahm KB. Synergism of Helicobacter
pylori infection and stress on the augmentation of gastric mucosal damage
and its prevention with alpha-tocopherol. Free Radic Biol Med. 2005 Jun
1;38(11):1447-57.
4)
Cheong JY, Lee KM, Cho SW, Won JH, Kim JK,
Wang HJ, Hahm KB, Kim JH
Survival benefits of intra-arterial infusion
chemotherapy in patients with advanced
hepatocellular carcinoma with portal vein tumor
thrombosis. Hepatol Res. 2005 Apr 30
5)
Yoo BM, Oh TY, Kim YB, Yeo M, Lee JS, Surh
YJ, Ahn BO, Kim WH, Sohn S, Kim JH,
Hahm
KB.
Novel antioxidant ameliorates the fibrosis and inflammation of
cerulein-induced chronic pancreatitis in a mouse model.
Pancreatology 2005;5(2-3):165-76.
6)
Yoo BM, Yeo M, Oh TY, Choi JH, Kim WW, Kim
JH, Cho SW, Kim SJ, Hahm KB.
Amelioration of pancreatic fibrosis in mice with
defective TGF-beta signaling. Pancreas 2005
Apr;30(3):71-9.
7)
Lee JS, Oh TY, Kim YK, Baik JH, So S, Hahm KB, Surh YJ. Protective
effects of green
tea polyphenol extracts against ethanol-induced
gastric mucosal damages in rats:
stress-responsive transcription factors and MAP
kinases as potential targets. Mutat Res. 2005 Nov
11;579(1-2):214-24.
8)
Park S, Yeo M, Jin JH, Lee KM, Jung JY, Choue R, Cho SW, Hahm KB. Rescue of
Helicobacter pylori-induced cytotoxicity by red
ginseng. Dig Dis Sci. 2005
Jul;50(7):1218-27.
2004
1)
Yeo M, Kim DK, Kim YB, Oh TY, Lee JE, Cho
SW, Kim HC, Hahm KB. Selective
induction of apoptosis with proton pump inhibitor in gastric cancer cells. Clin
Cancer Res. 2004 Dec 15;10(24):8687-96.
2)
Lee KM, Yeo M, Choue JS, Jin JH, Park SJ,
Cheong JY, Lee KJ, Kim JH, Hahm KB.
Protective mechanism of epigallocatechin-3-gallate against Helicobacter pylori-induced gastric epithelial cytotoxicity via the
blockage of TLR-4 signaling.
Helicobacter. 2004
Dec;9(6):632-42.
3)
Nam KT, Hahm KB, Oh SY, Yeo M, Han SU, Ahn B, Kim YB, Kang JS, Jang DD,
Yang KH, Kim DY. The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter
pylori -
associated gastric cancer development in a mouse model. Clin Cancer Res. 2004
Dec 1;10(23):8105-13.
4)
Yeo M, Park HK, Kim DK, Cho SW, Kim YS, Cho
SY, Paik YK, Hahm KB. Restoration of
heat shock protein70 suppresses gastric mucosal inducible nitric oxide synthase
expression induced by Helicobacter pylori.
Proteomics. 2004 Nov;4(11):3335-42.
5)
Nam KT, Oh SY, Ahn B, Kim YB, Jang DD, Yang
KH, Hahm KB, Kim DY. Decreased Helicobacter pylori associated gastric
carcinogenesis in mice lacking inducible nitric oxide synthase. Gut 2004
Sep;53(9):1250-5.
6)
Yeo M, Park HK, Lee KM, Lee KJ, Kim JH, Cho
SW, Hahm KB. Blockage of HSP 90
modulates Helicobacter pylori-induced
IL-8 productions through the inactivation of transcriptional factors of AP-1
and NF-kappaB. Biochem Biophys Res Commun. 2004 Jul 30;320(3):816-24.
7)
Park S, Hahm KB, Oh TY, Jin JH, Choue R. Preventive effect of the
flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats. Dig
Dis Sci. 2004 Mar;49(3):384-94
8)
Park S, Kim WS, Choi UJ, Han SU, Kim YS,
Kim YB, Chung MH, Nam KT, Kim DY, Cho
SW, Hahm KB. Amelioration of oxidative stress with ensuing inflammation
contributes to chemoprevention of H.
pylori-associated gastric carcinogenesis. Antioxid Redox Signal. 2004
Jun;6(3):549-60.
9)
Kwon HJ, Kang JO, Cho SH, Kang HB, Kang KA,
Kim JK, Kang YS, Song BC, Kang HW, Shim MJ, Kim HS, Kim YB, Hahm KB, Kim BJ, Kook MC, Chung MH,
Hyun JW. Presence of human mycoplasma DNA in gastric tissue samples from Korean
chronic gastritis patients. Cancer Sci. 2004 Apr;95(4):311-5.
2003
1)
Hahm
KB,
Kim DH, Lee KM, Lee JS, Surh YJ, Kim YB, Yoo BM, Kim JH, Joo HJ, Cho YK, Nam
KT, Cho SW. Effect of long-term administration of rebamipide on Helicobacter pylori infection in mice.
Aliment Pharmacol Ther. 2003 Jul;18 Suppl 1:24-38
2)
Choi J, Kim DY, Hyun JW, Yoon SH, Choi EM, Hahm KB, Rhee KH, Chung MH Measurement
of oxidative damage at individual gene levels by quantitative PCR using
8-hydroxyguanine glycosylase (OGG1). Mutat Res. 2003 Feb-Mar;523-524:225-35.
3)
Hahm
KB,
Song YJ, Oh TY, Lee JS, Surh YJ, Kim YB, Yoo BM, Kim JH, Han SU, Nahm KT, Kim
MW, Kim DY, Cho SW. Chemoprevention of Helicobacter
pylori-associated gastric carcinogenesis in a mouse model: is it possible?
J Biochem Mol Biol. 2003 Jan 31;36(1):82-94.
4)
Kim DH, Kim SW, Song YJ, Oh TY, Han SU, Kim
YB, Joo HJ, Cho YK, Kim DY, Cho SW, Kim MW, Kim JH, Hahm KB. Long-term evaluation of mice model infected with Helicobacter pylori: focus on gastric
pathology including gastric cancer. Aliment Pharmacol Ther. 2003 Jul;18 Suppl
1:14-23.
2002
1)
Lee
KM, Cho SW, Kim SW, Kim HJ, Hahm KB,
Kim JH. Effect of virological response on post-treatment durability of
lamivudine-induced HBeAg seroconversion. Journal of Viral Hepatitis 2002;
9:208-212
2)
Hahm
KB,
Lim HY, Sohn S, Kwon HJ, Lee KM, Lee JS, Surh YJ, Kim YB, Joo HJ, Kim WS, Cho
SW.In vitro evidence of the role of COX-2 in attenuating gastric inflammation
and promoting gastric carcinogenesis. J Environ Pathol Toxicol Oncol.
2002;21(2):165-76
3)
Han SU, Kim YB, Joo HJ, Hahm KB, Lee WH, Cho YK, Kim DY, Kim
MW. Helicobacter pylori infection
promotes gastric carcinogenesis in a mice model. J Gastroenterol Hepatol. 2002
Mar;17(3):253-61.
4)
Hahm
KB,
Lee KM, Kim YB, Hong WS, Lee WH, Han SU, Kim MW, Ahn BO, Oh TY, Lee MH, Green
J, Kim SJ. Conditional loss of TGF-beta signalling leads to increased
susceptibility to gastrointestinal carcinogenesis in mice. Aliment Pharmacol
Ther. 2002 Apr;16 Suppl 2:115-27.
5)
D Choi KW, Lee YC, Chung IS, Lee JJ, Chung
MH, Kim NY, Kim SW, Kim JG, Roe IH, Lee SW, Jung HY, Choi MG, Hahm KB, Hong WS, Kim JH. Effect of
rebamipide in treatment of Helicobacter
pylori-associated duodenal ulcer: attenuation of chemokine expression and
nitrosative damage. Dig Dis Sci. 2002 Feb;47(2):283-91.
2001
1)
Hahm KB,
Im YH, Parks TW, Green J, M Sandford, Kim SJ : Loss of TGF-? signaling in the
intestine contributes to tissue injuries in inflammatory bowel disease. Gut
49:190-198, 2001
2)
Im YH, Kim HT, Kim IY, Factor VM, Hahm
KB, Anzano M, Jang JJ, Flanders K, Haines DC, Thorgeirsson SS, Sizeland A,
Kim SJ: Heterozygous mice for the TGF-? type II receptor gene have increased
susceptibility to hepatocellular carcinogenesis. Cancer Res 61:6665-6668, 2001
3)
Chang J, Lee C, Hahm KB, Yi Y, Choi
SG, Kim SJ: Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related
transcription factor, induces endogenous TGF-beta type II receptor expression
and restores the TGF-beta signaling pathway in Hs578t human breast cancer
cells. Oncogene. 19:151-154: 2000
4)
Oh TY, Lee JS, Ahn BO, Cho H, Kim WB, Kim
YB, Surh YJ, Cho SW, Lee KM, Hahm KB.
Oxidative stress is more important than acid in the pathogenesis of reflux
esophagitis in rats. Gut 3:364-371, 2001
5)
Oh TY, Lee JS, Ahn BO, Cho H, Kim WB, Surh
YJ, Cho SW, Hahm KB. Oxidative
damages are more critical in pathogenesis of reflux esophagitis: Implication of
antioxidant in its treatment. Free Rad Biol Med 15:905-915, 2001
6)
Hahm
KB,
Lee JS, Oh TY, Ahn BO, Kim WB, Kim YB, Cho SW, Surh YJ: Involvement of
oxidative stress in experimentally induced reflux esophagitis and Barrett’s
esophagus: Clue for the chemoprevention of esophageal carcinoma by
antioxidant. Mutation Res 480:189-200, 2001
7)
Ahn BO, Ko KW, Oh TY, Cho H, Kim WB, Lee
KJ, Cho SW, Hahm KB. Efficacy of use
of colonoscopy in dextran sulfate sodium induced ulcerative colitis in
rats: the evaluation of the effects of antioxidant by colonoscopy. Int J
Colorectal Dis 16:174-181, 2001
8)
Kim JH, Yoo BM, Lee KJ, Hahm KB, Cho SW, Park JJ, Kim SS, Park
HC, Kim JH Self expanding coil stent with a long delivery system for palliation
of unresectable malignant gastric outlet obstruction: a prospective study.
Endoscopy 2001 Oct;33(10):838-42.
2000
1)
Lee KJ, Kim JH, Hahm KB, Cho SW,
Park SY: Randomized trial of N-butyl -2- cyanoacrylate compared with injection
of hypertonic saline-epinephrine in the endoscopic treatment of bleeding peptic
ulcers. Endoscopy 32:505-511: 2000
2)
Hahm
KB,
Im YH, Lee C, Parks WT, Bang YJ, Green J, Kim SJ : Loss of TGF-beta signaling
contributes to autoimmune pancreatitis. J Clin Invest. 105:1057-1065: 2000
3)
Cho SW, Hahm KB, Kim JH: Reversion
from precore/core promoter mutants to wild-type hepatitis B virus during the
course of lamivudine therapy. Hepatology. 32:1163-1169: 2000
4)
Chang J, Lee C, Hahm KB, Yi Y, Choi SG, Kim SJ. Over-expression of
ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous
TGF-beta type II receptor expression and restores the TGF-beta signaling
pathway in Hs578t human breast cancer cells. Oncogene 2000 Jan 6;19(1):151-4.
5)
Lee GH, Kim JH, Lee KJ, Yoo BM, Hahm KB, Cho SW, Park YS, Moon YS Life-threatening intraabdominal arterial
embolization after histoacryl injection for bleeding gastric ulcer. Endoscopy
2000 May;32(5):422-4.
1999
1) Hahm KB, Cho K, Lee C, Im YH, Chang J, Choi SG, Sorensen PH, Thiele CJ, Kim SJ Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nature Genet 23:222-227, 1999
2) Kim YS, Cho SW, Lee KJ, Hahm KB, Wang HJ, Yim H, Jin YM, Park CH. Tc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma. Clin Nucl Med. 1999 Nov;24(11):874-9.
1998
1)
Hahm
KB,
Lee KJ, Kim YS, Kim JH, Cho SW, Yim H, Joo HJ: Quantitative and qualitative
usefulness of rebamipide in eradication regimen of Helicobacter pylori.
Dig Dis Sci. 43:192-197: 1998
2)
Hahm
KB,
Lee KJ, Kim JH, Cho SW, Chung MH : Helicobacter pylori infection,
oxidative DNA damage, gastric carcinogenesis, and reversibility by
rebamipide. Dig Dis Sci. 43:72-77: 1998
3)
Hahm
KB, Kim JH, Yoo BM, Kim YS, Cho SW, Yim
H, Ahn BO, Kim WB: Induction of apoptosis with an extract of Artemisia asiatica
attenuates the severity of cerulein-induced pancreatitis in
rats. Pancreas.17:153-157: 1998.
4)
Hahm
KB,
Lee KJ, Kim YS, Kim JH, Cho SW, Yim H, Joo HJ: Augmented eradication rates of Helicobacter pylori by new combination
therapy with lansoprazole, amoxicillin, and rebamipide. Dig Dis Sci.
43:235-240: 1998
5)
Choi SG, Yi Y, Kim YS, Kato M, Chang J,
Chung HW, Hahm KB, Yang HK, Rhee HH Bang YJ, Kim SJ: A novel ets-related
transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming
growth factor-beta type II receptor. J Biol Chem. 273:110-117: 1998
6)
Bae WY, Yoo BM, Lee KJ, Kim YS, Hahm KB, Kim JH, Cho SW. Application of
clips during ERCP: a new anchoring method for redundant Kerckring's fold
covering the duodenal papilla. Endoscopy. 1998 Jan;30(1):S5-6.
1997
1)
Hahm
KB,
Park IS, Kim YS, Kim JH, Cho SW, Lee SI, Youn JK. Role of rebamipide on induction of heat-shock proteins
and protection against reactive oxygen metabolite - mediated cell damage in
cultured gastric mucosal cells. Free Radic Biol Med. 1997;22(4):711-6.
2)
Lee KJ, Hahm KB, Kim YS, Kim JH, Cho SW, Jie H, Park CH, Yim H. The
usefulness of Tc-99m HMPAO labeled WBC SPECT in eosinophilic gastroenteritis.
Clin Nucl Med. 1997 Aug;22(8):536-41.
3)
Hahm
KB,
Lee KJ, Choi SY, Kim JH, Cho SW, Yim H, Park SJ, Chung MH. Possibility of
chemoprevention by the eradication of Helicobacter
pylori: oxidative DNA damage and apoptosis in H. pylori infection. Am J Gastroenterol. 1997 Oct;92(10):1853-7.
Grants in Progress (National Grants)
1. Disease Genomics Research Center (2002-2006)
2. Grants from Korea Food Research (2005-2006)
3. Grant from Korea Ginseng Society (2004-2009)
4. Grant from the Ministry of Health and Family Affair (2008-2014, 2016-2020)
5. Grant from the Ministry of Education and Science (2009-2014, 2014-2017)
6. Grant from Chungchung Province Project (2012-2015)
7. Grant from the Ministry of Agriculture and Fishery (2016-2018)
8. Grant from California Walnit Commission (2016-2018)